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991.
992.
Anabel Negredo Rafael Snchez-Arroyo Francisco Díez-Fuertes Fernando de Ory Marco Antonio Budio Ana Vzquez ngeles Garcinuo Lourdes Hernndez Csar de la Hoz Gonzlez Almudena Gutirrez-Arroyo Carmen Grande Paz Snchez-Seco 《Emerging infectious diseases》2021,27(4):1211
In August 2018, a fatal autochthonous case of Crimean-Congo hemorrhagic fever was confirmed in western Spain. The complete sequence of the viral genome revealed circulation of a new virus because the genotype differs from that of the virus responsible for another case in 2016. Practitioners should be alert to possible new cases. 相似文献
993.
Vania Macías‐Calvio Luz‐María Fuentealba María‐Paz Marzolo 《Journal of neuroscience research》2021,99(1):163-179
Parkinson's disease (PD) is a highly prevalent neurodegenerative condition. The disease involves the progressive degeneration of dopaminergic neurons located in the substantia nigra pars compacta. Among late‐onset, familial forms of Parkinson are cases with mutations in the PARK17 locus encoding the vacuolar protein sorting 35 (Vps35), a subunit of the retromer complex. The retromer complex is composed of a heterotrimeric protein core (Vps26‐Vps35‐Vps29). The best‐known role of retromer is the retrieval of cargoes from endosomes to the Golgi complex or the plasma membrane. However, recent literature indicates that retromer performs roles associated with lysosomal and mitochondrial functions and degradative pathways such as autophagy. A common point mutation affecting the retromer subunit Vps35 is D620N, which has been linked to the alterations in the aforementioned cellular processes as well as with neurodegeneration. Here, we review the main aspects of the malfunction of the retromer complex and its implications for PD pathology. Besides, we highlight several controversies still awaiting clarification. 相似文献
994.
Guillermo Alberto Pablo Barbero Rosa Liascovich María Paz Bidondo Boris Groisman 《American journal of medical genetics. Part A》2020,182(5):1084-1092
The objectives of this study were to describe the birth prevalence of limb reduction defects (LRD) in Argentina, their clinical features, and to review the literature on this topic. The data source was the National Network of Congenital Anomalies of Argentina, a surveillance system that has been operative since 2009. Data were collected from November 1, 2009 to December 31, 2016. 1,663,610 births and 702 affected patients were registered during this period. The prevalence of LRD was 4.22/10,000 births (CI 95%: 3.93–4.54). In 15,094 stillbirths, prevalence was 30.80/10,000 (CI 95%: 22.31–40.65). Perinatal mortality (stillbirths plus early neonatal deaths) was 24.6%, mostly explained by postnatal deaths. LRD were classified according to different variables, including Gold's anatomic classification. Then, 41.0% of patients had transverse terminal defects and 50.2% had longitudinal defects. We found multiple and syndromic clinical presentation to be associated with both preaxial LRD and lethality. The prevalence of LRD was lower and perinatal mortality was higher in our study compared to that of previously published studies. Because there is heterogeneity in the inclusion and exclusion criteria among publications, a greater effort should be made in order to include similar populations and to use a unified anatomic classification and nomenclature. 相似文献
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María Begoña Carroza Escobar Jovita Ortiz Contreras María Paz Bertoglia Marcela Araya Bannout 《Obesity research & clinical practice》2021,15(1):73-77
ObjectiveTo evaluate whether pregestational obesity is associated with the risk of caesarean section in pregnant women living in a country in an advanced stage of the obstetric transition.MethodsRetrospective cohort study. Data were collected from prenatal and hospital records. Pregestational obesity was defined as: body mass index, [weight(k)/height (m2)] ≥30, and caesarean sections were categorized as elective, emergency, or non-emergency/medically necessary. Biodemographic and sociodemographic characteristics, obstetric and perinatal pathologies, and maternal anthropometric variables were assessed. Chi-square and t-tests were used to compare qualitative and quantitative variables, respectively. Simple and adjusted generalized linear models were used to evaluate the association between pregestational obesity and caesarean delivery. Finally, population attributable risk was calculated. Data analysis was performed using STATA.v.14.0.Participants2309 pregnant women with a singleton pregnancy who gave birth at a public hospital in the Metropolitan Region of Santiago, Chile in 2015.ResultsThe prevalence of pregestational obesity was 21.4%, and the incidence of caesarean deliveries was 34.8% (33% of which corresponded to elective, 46% to emergency, and 21% to non-emergency/medically necessary caesarean deliveries). Pregestational obesity increased the risk of caesarean delivery (aRR = 1.46; 95%CI. [1.19–1.79] as well as the risk of elective (aRR = 1.74; 95%CI. [1.23–2.45]) and emergency caesarean delivery (aRR = 1.44; 95%CI. [1.03–2.00]). The population attributable risk of pregestational obesity for caesarean section was 32%.ConclusionGiven the significant association between pregestational obesity and caesarean delivery, it is necessary to develop strategies to decrease obesity among women of childbearing age in order to decrease obstetric intervention. 相似文献
998.
999.
Tomás José González-López Blanca Sánchez-González Isidro Jarque Silvia Bernat Fernando Fernández-Fuertes Isabel Caparrós Inmaculada Soto Angeles Fernández-Rodríguez Estefanía Bolaños Gloria Pérez-Rus Cristina Pascual José Angel Hernández-Rivas Elsa López-Ansoar Marta Gómez-Nuñez Violeta Martínez-Robles Pavel Olivera Maria Yera Cobo María Jesús Peñarrubia Carmen Fernández-Miñano Erik de Cabo María Paz Martínez Badas Germán Perdomo Luis Javier García-Frade 《European journal of haematology》2020,104(3):259-270
1000.
Matthew R. Callstrom MD PhD Damian E. Dupuy MD Stephen B. Solomon MD Robert A. Beres MD Peter J. Littrup MD Kirkland W. Davis MD Ricardo Paz‐Fumagalli MD Cheryl Hoffman MD Thomas D. Atwell MD J. William Charboneau MD Grant D. Schmit MD Matthew P. Goetz MD Joseph Rubin MD Kathy J. Brown Paul J. Novotny MS Jeff A. Sloan PhD 《Cancer》2013,119(5):1033-1041